Mira Loma Invitational - CA — Designer Genes

A gene normally produces a protein that is 300 amino acids long. After mutation, the protein produced is 95 amino acids long. Which mutation most likely caused this change?

Vincristine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

Cell 1 has half as much DNA as cells 2, 3, and 4 in a mitotically active tissue. Cell 1 is most likely in

One difference between normal cells and cancer cells is that normal cells

Karyotyping is a technique used to display condensed chromosomes arranged in pairs. Which phase of mitosis are the cells arrested in for this procedure?

Which of the following is true about crossing over? Check all that apply.

What is the primary structural reason why plant cells cannot undergo cytokinesis through the formation of a cleavage furrow like animal cells?

Exposure to ultraviolet radiation is most directly associated with which type of DNA damage?

If the DNA content of an animal diploid cell is x in the G1 phase of the cell, the DNA content of the same cell at metaphase I of meiosis and metaphase II of meiosis will be respectively

If a couple has two children, one of whom is affected by an autosomal recessive disorder, even though neither parent is affected, what can we infer about the couple's genotypes?

An allele is defined as

Sasha and Adam each have a sibling with sickle cell disease. Neither Sasha nor Adam nor any of their parents has the disease, and none of them has ever been tested to see if they carry the sickle cell allele. Based on this incomplete information, calculate the probability that if this couple has a child, the child will have sickle cell disease.

In cattle, the polled (absence of horns) condition is dominant over the horned, and two codominant alleles control the coat color. The genotype RR produces a red coat color, RW produces a roan coat, and WW produces a white coat. A dairy farmer crossed a PpRW bull with a ppWW cow. What is the probability that the offspring of this cross will be polled white?

In a population of Caucasian-Americans, we find that 1 out of every 2500 people has sickle cell disease. The inheritance of this trait is autosomal recessive. What proportion of individuals in this population would be expected to be heterozygous carriers of the cystic fibrosis gene?

The Synaptonemal complex is responsible for

Which of the following organelles is most commonly associated with maternal inheritance?

A rare blood group interaction where an individual lacks the "H substance" (gene h). Even if they have the genes for Blood Type A or B, they will test as Type O because the hh genotype prevents the A and B antigens from attaching to the blood cells. The above phenomenon is an example of

Match the protein to its function in DNA synthesis

Meiosis I is similar to mitosis in that

The spontaneous loss of amino groups from adenine in DNA results in hypoxanthine, an uncommon base, opposite thymine. What combination of proteins could repair such damage?

Which of the following pairs of base sequences could form a short stretch of a normal DNA double helix?

Visual Skills: Write a short answer. What phase of mitotic cell division are each of the cells in the pictures below identified by the pointer in?

A ____

Identify the part labeled B in the figure.

Identify the part labeled C in the figure.

Identify the part labeled D in the figure.

A man who has alkaptonuria [a disorder of amino acid metabolism] marries a woman who has hereditary sucrose intolerance. Both are autosomal recessive diseases, and both map to 3q with a distance of 10cM separating the two loci. What is the chance they will have a child with alkaptonuria and sucrose intolerance?

A segment of a gene is shown below:

Original DNA sequence: ATG-GAA-CTT-ACC-TGA

After mutation, the sequence becomes: ATG-GAA-TTC-TAC-CTG-A

Which conclusion is best supported by the data?

If the concentration of agarose in a gel is increased, what effect would this have on DNA fragment separation?

Which mutation would result in continuous transcription of the lac operon regardless of lactose presence?

A microarray experiment compares cancer cells (sample A) and normal cells (sample B). A gene shows high red fluorescence (sample A) and low green fluorescence (sample B). This means:

DNA methylation usually occurs on which of the following residues and typically has what effect on gene expression?

The formation of the Philadelphia chromosome in Chronic myelogenous leukemia is an example of

Enzymes that break down DNA catalyze the hydrolysis of the covalent bonds that join the nucleotides together. What would happen to DNA molecules treated with these enzymes?

Which of the following enzymes is NOT required for PCR?

A pedigree shows that an affected female and an unaffected male produce all affected sons and all unaffected daughters. Which inheritance pattern best explains this

When tryptophan is abundant, what happens to the trp operon?

Which of the following sequences in the double-stranded DNA is most likely to be recognized as a cutting site for a restriction enzyme?

The following is a pedigree of a family across three generations. What is the most likely nature of the inheritance shown in the pedigree chart [affected individuals are represented as darkened shapes, circle-female, square- male]

What molecules are the key molecules that are relied upon in Sanger sequencing technology?

Which is most likely to be true of a human cell with 22 chromosomes and 1 X chromosome?

Which type of DNA polymerase is used in PCR and why?

Which statement is true about bacterial transposons and antibiotic resistance?

Which statement illustrates a challenge caused by pleiotropy in medicine?

In FISH, why are the chromosomes denatured before adding the probe?

Women with Turner syndrome have cells of different genotypes or chromosome constitutions within a single individual. Some women have somatic cells that are 45, X, and others that are 46, XX or 47, XXX. What is this condition of inheritance called

Which histone modification is associated with gene silencing?

If two genes are linked, what can be concluded about their inheritance pattern?

Which of the following best describes the composition and function of a spliceosome?

Unlike most genes in the human body, the genes for antibodies (immunoglobulins) are not "ready-to-use" in the germline DNA. Which of the following best describes the process of V(D)J recombination?

A geneticist is mapping three genes— A , B , and C —on a single chromosome. Through a series of crosses, the following recombination frequencies were determined: ● A to B: 8% ● B to C: 15% ● A to C: 23% What is the correct linear order of these genes on the chromosome?